منابع مشابه
Amyloid Oligomer Structures and Toxicity
Amyloid accumulation is commonly associated with a number of important human degenerative diseases and recent findings indicate that soluble amyloid oligomers may represent the primary pathological species in degenerative diseases. Amyloid oligomers are structurally and morphologically diverse, raising the question on whether this diversity is pathologically significant and whether different ty...
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Patients with Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, chiefly suffer from impairment of memory and other cognitive functions. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins, respectively. Recently, a new concept has emerged: that soluble oli...
متن کاملSimulation study of the contribution of oligomer/oligomer binding to capsid assembly kinetics.
The process by which hundreds of identical capsid proteins self-assemble into icosahedral structures is complex and poorly understood. Establishing constraints on the assembly pathways is crucial to building reliable theoretical models. For example, it is currently an open question to what degree overall assembly kinetics are dominated by one or a few most efficient pathways versus the enormous...
متن کاملHierarchical condensation
he movements of cilia and flagella are driven by axonemal dynein ATPases, whose activity must be coordinated in space and time. On page 47, Rupp and Porter provide the first molecular characterization of a component of the dynein regulatory complex (DRC), a crucial but poorly understood regulator of flagellar movement. Besides suggesting a model for DRC assembly, the work identifies a possible ...
متن کاملProtein Condensation.
Works intended for this column should be sent direct to the Book-Review Editor, whose address appears in this issue. All reviews are also available from Crystallography Journals Online, supplemented where possible with direct links to the publisher's information. The following books have been received by the Editor. Uncritical notices are given under this heading instead of reviews in order to ...
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ژورنال
عنوان ژورنال: Kobunshi
سال: 1966
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.15.510